Fate of intraperitoneally injected liver metallothionein in rat kidney.
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چکیده
منابع مشابه
The fate of large doses of creatine injected intraperitoneally into normal rats.
Four young adult male rats were given an intraperitoneal injection of 227 mg. creatine and their urines collected for 48 hr. The creatine and creatinine in the carcass and urine of these 4 rats and in those of 4 control rats were determined. Eighty-nine per cent of the injected dose was recovered-83% in the urine and 6% in the carcass. The data are interpreted to indicate that there was no sign...
متن کاملThe Cellular Reaction to Intraperitoneally Injected Blood *
The well-known variation in the reactions to hemorrhage in the tissues is the basis of the study presented in this report, dealing primarily with the changes that occur in the extravasated red blood cells and particularly with the monocytic response. The problems of the fat and iron partides found both in the monocytes and elsewhere in the vicinity of hemorrhage are considered in detail, and th...
متن کاملTemporal changes in metallothionein gene transcription in rat kidney and liver: relationship to content of mercury and metallothionein protein.
Metallothioneins are encoded by a family of genes that are induced by inorganic mercury. Despite the well-characterized acute response of metallothionein (MT) genes in the kidneys and liver after a single exposure to inorganic mercury, relatively little is known about the activity of these genes and the content of MT protein during prolonged periods after exposure. Rats treated with inorganic m...
متن کاملEffects of intraperitoneally injected silver nanoparticles on histological structures and blood parameters in the albino rat
BACKGROUND The purpose of this study was to investigate the effect of acute dosing with silver nanoparticles (AgNPs) and identify potential ultrastructural alterations in the liver and kidney and their effect on blood parameters in the albino rat. METHODS Twenty rats were used to assess the acute effects of AgNPs. Rats in the treatment group were injected intraperitoneally with 0.5 mL of dist...
متن کاملEffects of nickel chloride and diethyldithiocarbamate on metallothionein in rat liver and kidney.
Effects of NiCl2 and sodium diethyldithiocarbamate (DDC) upon metallothionein (MT) concentrations were studied in liver and kidney of male Fischer rats. After injection of NiCl2 (0.75 mmol per kg, sc), hepatic MT concentration increased 2.6-fold at 6.5 hr and 8.2-fold at 17 hr; renal MT concentration increased 1.4-fold at 6.5 hr and 2.3-fold at 17 hr. Dose-related increases of MT concentrations...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1979
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.27.647